トランスレーショナルリサーチ研究

  1. 血液中の腫瘍由来遊離核酸を用いた、非侵襲的な神経芽腫予後不良因子の診断法の確立

    血液中の腫瘍由来遊離核酸を用いた神経芽腫のMYCN遺伝子増幅診断
    Gotoh T, Hosoi H, Iehara T, Kuwahara Y, Osone S, Tsuchiya K, Ohira M, Nakagawara A, Kuroda H, Sugimoto T. Prediction of MYCN amplification in neuroblastoma using serum DNA and real-time quantitative polymerase chain reaction. J Clin Oncol. 23:5205-5210, 2005.

    Yagyu S, Iehara T, Tanaka S, Gotoh T Misawa-Furihata A, Sugimoto T, London WB, Hogarty MD, Teramukai S, Nakagawara A, Hiyama E, Maris JM, Hosoi H. Serum-Based Quantification of MYCN Gene Amplification in Young Patients with Neuroblastoma: Potential Utility as a Surrogate Biomarker for Neuroblastoma. Plos One 11(8) e0161039. 2016

    血液中の腫瘍由来遊離核酸を用いたがん遺伝子のメチル化異常の診断
    Misawa A, Tanaka S, Yagyu S, Tsuchiya K, Iehara T, Sugimoto T, Hosoi H.RASSF1A hypermethylation in pretreatment serum DNA of neuroblastoma patients: a prognostic marker. Br J Cancer. 2009 Jan 27;100(2):399-404.

    Yagyu S, Gotoh T, Iehara T, Miyachi M, Katsumi Y, Tsubai-Shimizu S, Kikuchi K, Tamura S, Tsuchiya K, Imamura T, Misawa-Furihata A, Sugimoto T, Sawada T, Hosoi H. Circulating methylated-DCR2 gene in serum as an indicator of prognosis and therapeutic efficacy in patients with MYCN nonamplified neuroblastoma. Clin Cancer Res. 2008 Nov 1;14(21):7011-9.

    血液中の腫瘍由来遊離核酸を用いた染色体異常（11q loss ）の診断
    Yagyu S, Iehara T, Gotoh T, Miyachi M, Katsumi Y, Kikuchi K, Tsuchiya K, Osone S, Kuroda H, Sugimoto T, Sawada T, Hosoi. Preoperative analysis of 11q loss using circulating tumor-released DNA in serum: a novel diagnostic tool for therapy stratification of neuroblastoma.Cancer Lett. 2011;309(2):185-9.

  2. 血液中の腫瘍由来micro RNAを用いた横紋筋肉腫の診断法の確立

    Miyachi M, Tsuchiya K, Yoshida H, Yagyu S, Kikuchi K, Misawa A, Iehara T, Hosoi H. Circulating muscle-specific microRNA, miR-206, as a potential diagnostic marker for rhabdomyosarcoma.Biochem Biophys Res Commun. 2010; 400(1): 89-93.

  3. HLA不一致造血細胞移植における、HLA-flow法を用いた移植後微小残存病変の検出

    Miyachi M, Watanabe E, Watanabe N, Tsuma Y, Kawashima-Goto S, Tamura S, Imamura T, Ishida H, Hosoi H. MRD detection of leukemia relapse using HLA typing by FACS in combination with FISH after mismatched allogeneic stem cell transplantation. Pediatr Transplant. 2014; 18(5): E180-184.