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臨床研究

日本小児がん研究グループ（JCCG/JPLSG）および、日本小児白血病研究会（JACLS）のメンバーとして、これらのグループが推進する臨床試験に積極的に関わっています。

特に急性リンパ性白血病については治療研究委員会の一員として、臨床試験の立案・運用に関わり、その成績の解析などにも関わっています。また、小児造血器腫瘍の診療における適切な支持療法の確立にむけた臨床研究にも取り組んでいます。

その他に、日本ランゲルハンス細胞組織球症研究会 (JLSG)の事務局を務めています。

基礎研究

  1. 難治性造血器腫瘍の遺伝子異常の解析と新規治療標的の探索

    小児急性リンパ性白血病および骨髄性白血病の遺伝子解析とくに融合遺伝子の機能解析を行い、より良い治療法の確立を目指して研究を行っています。

  2. 乳児急性リンパ性白血病のFLT3 CAR-Tによる治療可能性の検討
    乳児の急性リンパ性白血病のFLT3 CAR-Tによる治療を目指して研究を行っています。

研究メンバー

講師 今村俊彦
講師 大曽根眞也
助教 吉田秀樹
特任講師 加納　原
大学院生 岡本賢治
大学院生 眞弓あずさ
大学院生 末松正也
大学院生 浦田貴代
大学院生 田中誠治

所属学会

  • 日本小児血液・がん学会
  • 日本血液学会
  • 日本造血・免疫細胞療法学会
  • 米国血液学会

学会認定施設

  • 日本小児血液・がん専門医研修施設
  • 日本血液学会血液研修施設

業績

  1. Tomii T, Imamura T, Tanaka K, Kato I, Mayumi A, Soma E, Yano M, Sakamoto K, Mikami T, Morita M, Kiyokawa N, Horibe K, Adachi S, Nakahata T, Takita J, Hosoi H. Leukemic cells expressing NCOR1-LYN are sensitive to dasatinib in vivo in a patient-derived xenograft mouse model. Leukemia. 2020 Nov 16. doi: 10.1038/s41375-020-01091-3.

  2. Ishida H, Yano M, Hasegawa D, Hori T, Hashii Y, Kato K, Deguchi T, Saito A, Sato A, Hori H, Horibe K, Imamura T. Prednisolone poor response is not an indication for HSCT in pediatric B-cell precursor acute lymphoblastic leukemia in first remission: results from JACLS ALL-02 study. Int J Hematol. 2021. doi: 10.1007/s12185-021-03110-0.

  3. Kondo H, Kanayama T, Matsumura U, Urata T, Osone S, Imamura T, Inaba T, Hosoi H. Relapsed RUNX1-RUNX1T1-positive acute myeloid leukemia with pseudo-Chediak-Higashi granules. Int J Hematol. 2021. doi: 10.1007/s12185-021-03141-7.

  4. Kanayama T, Imamura T, Mayumi A, Soma E, Sakamoto K, Hayakawa F, Tanizawa A, Kiyokawa N, Hosoi H. Functional analysis of a novel fusion protein PAX5-KIDINS220 identified in a pediatric Ph-like ALL patient. Int J Hematol. 112(5): 714-719, 2020.

  5. Hasegawa D, Imamura T, Yumura-Yagi K, Takahashi Y, Usami I, Suenobu SI, Nishimura S, Suzuki N, Hashii Y, Deguchi T, Moriya-Saito A, Kato K, Kosaka Y, Hirayama M, Iguchi A, Kawasaki H, Hori H, Sato A, Kudoh T, Nakahata T, Oda M, Hara J, Horibe K; Japan Association of Childhood Leukemia Study Group (JACLS). Risk-adjusted therapy for pediatric non-T cell ALL improves outcomes for standard risk patients: results of JACLS ALL-02. Blood Cancer J. 10(2): 23, 2020.

  6. Tomizawa D, Miyamura T, Imamura T, Watanabe T, Saito A, Ogawa A, Takahashi Y, Hirayama M, Taki T, Deguchi T, Hori T, Sanada M, Ohmori S, Haba M, Iguchi A, Arakawa Y, Koga Y, Manabe A, Horibe K, Ishii E, Koh K. A risk-stratified therapy for infants with acute lymphoblastic leukemia: a report from the JPLSG MLL-10 trial. Blood. 136(16): 1813-1823, 2020.

  7. Usami I, Imamura T, Takahashi Y, Suenobu SI, Hasegawa D, Hashii Y, Deguchi T, Hori T, Shimada A, Kato K, Ito E, Moriya-Saito A, Kawasaki H, Hori H, Yumura-Yagi K, Hara J, Sato A, Horibe K. Discontinuation of L-asparaginase and poor response to prednisolone are associated with poor outcome of ETV6-RUNX1-positive pediatric B-cell precursor acute lymphoblastic leukemia. Int J Hematol. 109(4): 477-482, 2019.

  8. Sakamoto K, Shiba N, Deguchi T, Kiyokawa N, Hashii Y, Moriya-Saito A, Tomizawa D, Taga T, Adachi S, Horibe K, Imamura T. Negative CD19 expression is associated with inferior relapse-free survival in children with RUNX1-RUNX1T1-positive acute myeloid leukaemia: results from the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study. Br J Haematol. 187(3): 372-376, 2019.

  9. Mayumi A, Imamura T, Sakamoto K, Ota T, Osone S, Usami I, Hosoi H. Successful treatment with 2-chlorodeoxyadenosine of refractory pediatric Langerhans cell histiocytosis with initial involvement of the gastrointestinal tract. Int J Hematol. 110(6): 756-762, 2019.

  10. Sakamoto K, Imamura T, Kihira K, Suzuki K, Ishida H, Morita H, Kanno M, Mori T, Hiramatsu H, Matsubara K, Terui K, Takahashi Y, Suenobu SI, Hasegawa D, Kosaka Y, Kato K, Moriya-Saito A, Sato A, Kawasaki H, Yumura-Yagi K, Hara J, Hori H, Horibe K. Low incidence of osteonecrosis in childhood acute lymphoblastic leukemia treated with ALL-97 and ALL-02 study of Japan Association of Childhood Leukemia Study Group. J Clin Oncol. 36(9): 900-907, 2018.

  11. Tomoyasu C, Imamura T, Tomii T, Yano M, Asai D, Goto H, Shimada A, Sanada M, Iwamoto S, Takita J, Minegishi M, Inukai T, Sugita K, Hosoi H. Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes. Int J Hematol. 108(3): 312-8, 2018.

  12. Kanayama T, Imamura T, Kawabe Y, Osone S, Tahara J, Iwasaki F, Miyagawa N, Goto H, Imashuku S, Hosoi H. KMT2A-rearranged infantile acute myeloid leukemia masquerading as juvenile myelomonocytic leukemia. Int J Hematol. 108(6): 665-669, 2018.

  13. Yano M, Imamura T, Asai D, Deguchi T, Hashii Y, Endo M, Sato A, Kawasaki H, Kosaka Y, Kato K, Hori H, Yumura-Yagi K, Hara J, Oda M, Horibe K. Clinical significance of SH2B3 (LNK) expression in paediatric B-cell precursor acute lymphoblastic leukaemia. Br J Haematol. 183(2): 327-330, 2018.

  14. Sakamoto K, Imamura T, Kanayama T, Yano M, Asai D, Deguchi T, Hashii Y, Tanizawa A, Ohshima Y, Kiyokawa N, Horibe K and Sato A. Ph-like acute lymphoblastic leukemia with a novel PAX5-KIDINS220 fusion transcript. Genes Chromosomes Cancer. 56(4): 278-284, 2017.

  15. Kanayama T, Imamura T, Nakagawa N, Osone S, Hosoi H. Pediatric T-ALL complicated by irreversible nelarabine neurotoxicity. Pediatr Int. 59(7): 843-845, 2017.

  16. Osone S, Imamura T, Fukushima-Nakase Y, Kitamura-Masaki A, Kanai S, Imai T, Imashuku S, Kuroda H. Case reports of severe congenital neutropenia treated with unrelated cord blood transplantation with reduced-intensity conditioning. J Pediatr Hematol Oncol. 38(1): 49-52, 2016.

  17. Imamura T, Kiyokawa N, Kato M, Imai C, Okamoto Y, Yano M, Ohki K, Yamashita Y, Kodama Y, Saito A, Mori M, Ishimaru S, Deguchi T, Hashii Y, Shimomura Y, Hori T, Kato K, Goto H, Ogawa C, Koh K, Taki T, Manabe A, Sato A, Kikuta A, Adachi S, Horibe K, Ohara A, Watanabe A, Kawano Y, Ishii E, Shimada H. Characterization of pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia with kinase fusions in Japan. Blood Cancer J. 6: e419, 2016.

  18. Imamura T, Yano M, Asai D, Moriya-Saito A, Suenobu S-I, Hasegawa D, Deguchi T, Hashii Y, Kawasaki H, Hori H, Yumura-Yagi K, Hara J, Horibe K, Sato A. IKZF1 deletion is enriched in pediatric B-cell precursor acute lymphoblastic leukemia patients showing prednisolone resistance. Leukemia. 30(8): 1801-1803, 2016.

  19. Sakamoto K, Tanaka S, Tomoyasu C, Tomii T, Yano M, Takagi T, Yasuhiko T, Uoshima N, Komatsu H, Imamura T. Development of acute lymphoblastic leukemia with IgH-EPOR in a patient with secondary erythrocytosis. Int J Hematol. 104(6): 741-743, 2016.

  20. Osone S, Imamura T, Kanayama T, Tsuma Y, Kawashima-Goto S, Nakatani T, Sugimoto A, Takai A, Miyachi M, Tamura S, Ishida H, Hosoi H. Sorafenib therapy for pediatric acute myeloid leukemia with FMS-like tyrosine kinase 3-internal tandem duplication mutations: 2 case reports. J Pediatr Hematol Oncol. 39(4): e199-e202, 2016.