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神経グループは、小児神経専門医4名、てんかん専門医３名、臨床遺伝専門医２名が在籍しています。本学附属病院は、小児神経専門医、てんかん専門医、臨床遺伝専門医の認定研修施設となっているので、３つの小児神経関連の専門医取得が可能となっています。また、基礎研究にも力を入れており、学位取得も可能です。是非、興味のある方はお声をかけてください！

基礎研究

  • 発達性てんかん性脳症の分子病態解析
  • 遺伝性神経疾患のiPS細胞を用いた病態解析および新規治療の開発
  • ショウジョウバエを用いた小児神経疾患の新規治療探索
    （京都工芸繊維大学との共同研究）

AKT3遺伝子異常患者由来iPS細胞を用いた病態解析

  • 微小電極アレイ解析

  • 脳オルガノイド

脊髄性筋萎縮症のモデル

  • ショウジョウバエの神経筋接合部異常

研究メンバー

看護学科医学講座小児科学 教授 森本昌史
遺伝子診療部　病院准教授 千代延友裕
小児科学　学内講師 戸澤雄紀
小児科学　助教 一瀬栄佑
大学院生 宮本洋輔
大学院生 高田礼
大学院生 松浦周

関係学会

  • 日本小児神経学会
  • 日本てんかん学会
  • 日本人類遺伝学会

学会認定施設

  • 小児神経専門医制度認定研修施設
  • てんかん専門医制度認定研修施設
  • 臨床遺伝専門医制度認定研修施設

業績

  1. Miyamoto Y, Tozawa T, Ichise E, Hasegawa T, Fujimoto T, Itoh K, Morimoto M, Iehara T, Chiyonobu T. Functional verification and allele-specific silencing of a novel AKT3 variant that causes megalencephaly, polymicrogyria and intractable epilepsy. J Hum Genet. 70(5):281-285, 2025.

  2. Matsuoka T, Yoshida H, Kasai T, Tozawa T, Iehara T, Chiyonobu T. α-synuclein pathology in Drosophila melanogaster is exacerbated by haploinsufficiency of Rop: connecting STXBP1 encephalopathy with α-synucleinopathies. Hum Mol Genet. 2024; 33:1328-38.

  3. Taura Y, Tozawa T, Fujimoto T, Ichise E, Chiyonobu T, Itho K, Iehara T. Myosin Va, a novel interaction partner of STXBP1, is required to transport Syntaxin1A to the plasma membrane. Neuroscience. 2023; 524:256-68.

  4. Ichise E, Chiyonobu T, Ishikawa M, Tanaka Y, Shibata M, Tozawa T, Taura Y, Yamashita S, Yoshida M, Morimoto M, Higurashi N, Yamamoto T, Okano H, Hirose S. Impaired neuronal activity and differential gene expression in STXBP1 encephalopathy patient iPSC-derived GABAergic neurons. Hum Mol Genet. 2021; 30: 1337-48.

  5. Sakaue S, Hasegawa T, Sakai K, Zen Y, Tozawa T, Chiyonobu T, Yamada K, Morimoto M, Hosoi H. Low-grade IVH in preterm infants causes cerebellar damage, motor, and cognitive impairment. Pediatr Int. 2021; 63(11): 1327-33.

  6. Takai A, Chiyonobu T, Ueoka I, Tanaka R, Tozawa T, Yoshida H, Morimoto M, Hosoi H, Yamaguchi M. A novel Drosophila model for neurodevelopmental disorders associated with Shwachman-Diamond syndrome. Neurosci Lett. 2020; 739: 135449.

  7. Zen Y, Chiyonobu T, Yuge M, Yokota I, Morimoto M, Teramukai S, Hosoi H. Gender differences in occurrence of behavioral and emotional problems at the lower grades of elementary school: Association with developmental and behavioral characteristics at 5 years. Brain Dev. 2019; 41: 760-8.

  8. Hasegawa T, Yamada K, Tozawa T, Chiyonobu T, Tokuda S, Nishimura A, Hosoi H, Morimoto M. Cerebellar peduncle injury predicts motor impairments in preterm infants: A quantitative tractography study at term-equivalent age. Brain Dev. 2018; 40: 743-52.

  9. Yoshida M, Nakashima M, Okanishi T, Kanai S, Fujimoto A, Itomi K, Morimoto M, Saitsu H, Kato M, Matsumoto N, Chiyonobu T. Identification of novel BCL11A variants in patients with epileptic encephalopathy: Expanding the phenotypic spectrum. Clin Genet 2018; 93: 368-73.

  10. Zuiki M, Chiyonobu T, Yoshida M, Maeda H, Yamashita S, Kidowaki S, Hasegawa T, Gotoh H, Nomura T, Ono K, Hosoi H, Morimoto M. Luteolin attenuates interleukin-6-mediated astrogliosis in human iPSC-derived neural aggregates: A candidate preventive substance for maternal immune activation-induced abnormalities. Neurosci Lett. 2017; 653: 296-301.

  11. Kidowaki S, Morimoto M, Yamada K, Sakai K, Zuiki M, Maeda H, Yamashita S, Morita T, Hasegawa T, Chiyonobu T, Tokuda S, Hosoi H. Longitudinal change in white matter in preterm infants without magnetic resonance imaging abnormalities: Assessment of serial diffusion tensor imaging and their relationship to neurodevelopmental outcomes. Brain Dev. 2017; 39: 40-7.

  12. Yamashita S, Chiyonobu T, Yoshida M, Maeda H, Zuiki M, Kidowaki S, Isoda K, Morimoto M, Kato M, Saitsu H, Matsumoto N, Nakahata T, Saito MK, Hosoi H. Mislocalization of syntaxin-1 and impaired neurite growth observed in a human iPSC model for STXBP1-related epileptic encephalopathy. Epilepsia. 2016; 57: e81-6.

  13. Maeda H, Chiyonobu T, Yoshida M, Yamashita S, Zuiki M, Kidowaki S, Isoda K, Yamakawa K, Morimoto M, Nakahata T, Saito MK, Hosoi H. Establishment of isogenic iPSCs from an individual with SCN1A mutation mosaicism as a model for investigating neurocognitive impairment in Dravet syndrome. J Hum Genet. 2016; 61(6):565-9.

  14. Morita T, Morimoto M, Yamada K, Hasegawa T, Morioka S, Kidowaki S, Moroto M, Yamashita S, Maeda H, Chiyonobu T, Tokuda S, Hosoi H. Low-grade intraventricular hemorrhage disrupts cerebellar white matter in preterm infants: evidence from diffusion tensor imaging. Neuroradiology. 2015; 57: 507-14.

  15. Moroto M, Nishimura A, Morimoto M, Isoda K, Morita T, Yoshida M, Morioka S, Tozawa T, Hasegawa T, Chiyonobu T, Yoshimoto K, Hosoi H. Altered somatosensory barrel cortex refinement in the developing brain of Mecp2-null mice. Brain Res. 2013; 1537: 319-26.

  16. Morioka S, Morimoto M, Yamada K, Hasegawa T, Morita T, Moroto M, Isoda K, Chiyonobu T, Imamura T, Nishimura A, Morimoto A, Hosoi H. Effects of chemotherapy on the brain in childhood: diffusion tensor imaging of subtle white matter damage. Neuroradiology. 2013; 55: 1251-7.

  17. Tozawa T, Itoh K, Yaoi T, Tando S, Umekage M, Dai H, Hosoi H, Fushiki S. The shortest isoform of dystrophin (Dp40) interacts with a group of presynaptic proteins to form a presumptive novel complex in the mouse brain. Mol Neurobiol. 2012; 45: 287-97.

  18. Hasegawa T, Yamada K, Morimoto M, Morioka S, Tozawa T, Isoda K, Murakami A, Chiyonobu T, Tokuda S, Nishimura A, Nishimura T, Hosoi H. Development of corpus callosum in preterm infants is affected by the prematurity: in vivo assessment of diffusion tensor imaging at term-equivalent age. Pediatr Res. 2011; 69: 249-54.